ioGenetics proprietary technology comprises a protein engineering and manufacturing system and a suite of protein products.

Protein Engineering and Manufacturing

ioGenetics uses replication incompetent retroviral vectors to deliver genes to mammalian cell culture. This highly efficient gene transfer technology allows for single or multiple gene insertions per genome in a single transduction event. Cell lines derived from this process can be obtained within weeks, are stable and express product at levels that often out-compete other technologies. Due to their stability and productivity our cell lines can be used for large scale manufacturing in bioreactors.

In addition to cell culture, the retrovector constructs can also be used for injections into oocytes leading to generation of transgenic cattle with mammary-specific expression of protein products. This technology has been pioneered by the founders of ioGenetics and allows for scaling of production of recombinant products to volumes that are unattainable with current technologies.

Protein Products

ioGenetics' scientists are proficient in engineering recombinant antibodies and pattern recognition receptors to provide specific or broad-spectrum targeting of microorganisms. These targeting elements are used to deliver multiple biocides (recombinant enzymes or antimicrobial peptides) per targeting molecule to the surface of microbes, resulting in destruction of the membrane and death of the target microbe. The high affinity of the targeting component reduces the dosage needed, minimizing cost and toxicity. Functionality of the fusion proteins can be modified by the use of different spacer elements, truncations, or antibody isotypes.

Work is on-going to develop Directed Biocides™ effective against parasites, bacteria, fungi, and viruses.