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uTOPE™ analysis is a powerful immunoinformatics system developed at ioGenetics. uTOPE™ analysis enables integrated mapping of proteins to identify predicted B-cell epitopes, predicted MHC–I and MHC-II binding affinity and cross presentation across abroad array of HLA types, and protein topology mapping. The statistical methods underlying uTOPE™ mapping are based on principal component analysis of amino acids. The analytical output can be portrayed in high data-density graphics of epitope maps, in which patterns of epitope distribution are shown. uTOPE™ mapping is applicable to proteins of any source including microbial, mammalian, plant or synthetic biopharmaceutical proteins. A high throughput system, uTOPE™ analysis can be applied to whole microbial proteomes, or to compare epitopes conserved across microbial strains or protein isotypes. uTOPE™ analysis provides a reasoning environment for design of vaccines, diagnostics and antibodies, as well furthering the understanding of the immune response. It has applications in infectious diseases, allergy, autoimmunity and cancer biology.
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A highly efficient recombinant protein expression system which utilizes replication incompetent retrovectors to create stable protein producing mammalian cell lines enabling very rapid production and evaluation of new protein products, followed by seamless scale-up.
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Directed Biocide™ therapeutics are constructed using a design-build approach to create protein antimicrobial products by using a "toolbox" of protein subcomponents comprising antibody variable regions, antimicrobial peptides, enzymes and various functional linkers. By precisely targeting natural antimicrobials to specific microorganisms, the dose needed is reduced and therapeutic margins are increased. |
